Formulation And Evaluation pH Stimuli Sensitive Multiparticulate Delivery System Of Clarithromycin For The Treatment Of Helicobacter pylori

pH stimuli sensitive microspheres of clarithromycin were prepared on the principle of cation induced gelification, whereas, sodium alginate and pectin blend were cross linked with calcium chloride and investigated with regard to drug targeting specificity in the gastric mucosa. The microspheres were found to be discrete, spherical, free flowing and of monolithic matrix type. The yields of microspheres were found to varied 65±2 to 76±3%. Prepared microspheres have shown good mucoadhesive efficacy and anti microbial activity against isolated Helicobacter pylori strain. The following repeated oral administration of the formulation to Helicobacter pylori infected Mongolian gerbils was examined by polymerase chain reaction technique. It was found that the coated formulation was more effective than clarithromycin suspension. The results further substantiated that pH sensitive microspheres were found to adhere to the gastric or intestinal mucosa with high affinity might make contribution for complete eradication of Helicobacter pylori.